Network Enrichment Significance Testing in Brain-Phenotype Association Studies

Link to our paper

Introducing NEST method

Network Enrichment Significance Testing (NEST) is a powerful approach for evaluating the spatial specificity of brain-phenotype associations within functional brain networks (i.e., network enrichment). NEST addresses the need for a more rigorous and replicable framework for testing compared to traditional methods.

Quantification and Mapping:

• Quantifying and mapping vertex or voxel-level associations between measurements of brain structure/function and non-imaging phenotypes is central to many neuroimaging studies.

• We often refer to canonical functional networks to interpret what it means for associations to be strong/weak in different parts of the brain.

  • Helps understand neural mechanisms in transdiagnostic psychopathology.

  • Evaluates the strength or enrichment of brain-phenotype associations within networks.

Many neuroimaging studies involve interpreting maps of brain-phenotype associations through the lens of functional networks, but null hypotheses haven’t been well-defined, and methods are often ad hoc or rely on strong assumptions.​​

Challenges with Traditional Methods:

• Some methods have relied on subjective interpretations and unrealistic assumptions.

• Newer, more methodical approaches (e.g., spin test) may have inflated false positive rates.

NEST:

• Addresses gaps in existing methods

• General approach: adapts GSEA (Subramanian et al., 2005) to neuroimaging setting

  • Compares observed enrichment scores to a permutation-based null distribution to get a p-value

  • In a typical GSEA, researchers correlate mRNA expression profiles for many genes with a phenotype. In this setting, the null hypothesis (\(H_0\)) is that the correlations for genes in a pre-specific set are no higher than for genes outside that set.

• NEST null hypothesis: brain-phenotype associations observed within a network of interest are no more extreme than those observed outside the network.

  • Small p-values \(\implies\) evidence for enrichment within the network

• By adapting GSEA to the neuroimaging context through NEST, we can more accurately test the specificity of brain-phenotype associations to functional networks without compromising the spatial integrity of the data, which is a problem in previous methods.

Steps in the NEST Method:

Illustration of NEST, which adapts GSEA to test network enrichment in brain-phenotype association studies.​​

1. Quantify Associations:

   • Measure brain-phenotype associations at each location.

   • The choice of measurement method is flexible (e.g., partial correlation, regression coefficient estimates).

2. Sort Associations:

   • Arrange the brain-phenotype associations in descending order.

   • Locations with the strongest positive associations are at the top, and those with the strongest negative associations are at the bottom.

3. Identify Network-Specific Associations:

   • Identify the associations that fall within the pre-specified network of interest.

4. Calculate Running Sum:

   • Start with a running sum initialized to zero.

   • Update the running sum as you go through the sorted list.

5. Compute Enrichment Score:

   • Determine the enrichment score based on the maximum deviation from zero observed in the running sum.

6. Perform Permutations:

   • Shuffle the phenotype data across individuals multiple times.

   • For each permutation, repeat the steps of quantifying and sorting associations, and calculating the enrichment score.

7. Estimate p-value:

   • Compare the observed enrichment score to those obtained from permutations.

   • Estimate a p-value to evaluate the significance of the enrichment.

Implementations in R

The implementation of NEST is open-source and available in both R and Python. Researchers can easily use NEST by installing the ready-to-use package through devtools::install_github() in R or pip in Python. We hope this will allow researchers to easily apply NEST in their studies!

The following is a step-by-step guide for implementing NEST in R.

Install the package

if (!require(devtools)){
  install.packages("devtools")
}

## Loading required package: devtools

## Loading required package: usethis

devtools::install_github("smweinst/NEST")

## Skipping install of 'NEST' from a github remote, the SHA1 (67c65d35) has not changed since last install.
##   Use `force = TRUE` to force installation

library(NEST)

Prepare the data

Import necessary libraries for NEST:
- parallel for efficient parallel computing across multiple processor cores or machines to speed up computations.

library(parallel)
library(NEST)

Data used in our paper is publicly available in raw format here.

For the purpose of this software demonstration, we will illustrate NEST using publicly available preprocessed data from the HCP. This open access dataset has been made freely available to the research community by the WU-Minn HCP consortium.

Connectome workbench can be downloaded here.

HCP Tutorial data V1.5 can be downloaded here and behavioral data can be downloaded here, account required for both data.

Network partition labels can be found here.

Workbench can be downloaded here​.​

Brain-imaging data can be downloaded here​.​

Behavioral data can be downloaded here.​​

Network partition data can be downloaded here.

Once we get data ready, we will load them in R:

• Brain imaging data (e.g., freesurfer or cifti data) is loaded

library(ciftiTools)

## Warning: package 'ciftiTools' was built under R version 4.3.3

wb_path <- "/Users/binli/Documents/workbench/bin_macosxub" # specify your own path
ciftiTools.setOption("wb_path", wb_path)

## Using this Workbench path: '/Users/binli/Documents/workbench/bin_macosxub/wb_command'.

cifti <- read_cifti("./data/Q1-Q6_R440.All.sulc.32k_fs_LR.dscalar.nii")

## Warning in read_cifti_convert(cifti_fname, surfL_fname = surfL_fname, surfR_fname = surfR_fname, : Only the following brainstructures are present in the CIFTI file: left, right

sample_list <- cifti$meta$cifti$names
id_list <- sub("_Sulc","", sample_list)
X <- t(rbind(cifti$data$cortex_left, cifti$data$cortex_right))
print(dim(X))

## [1]   440 64984

# Visualize the CIFTI data
view_xifti_surface(cifti)

## `zlim` not provided: using color range -1.06 - 1.06 (data limits: -1.81 - 1.52).

• Load phenotype of interest (y) and covariates (Z)

behavior <- read.csv("./data/behavioral.csv", row.names="Subject")

library(stringr)
library(tibble)
calculate_average_age <- function(age_value) {
  if (grepl("^[0-9]+-[0-9]+$", age_value)) {
    # Check if the age value is a range
    bounds <- as.numeric(str_split(age_value, "-", simplify = TRUE))
    avg_age <- ceiling(mean(bounds))
    return(avg_age)
  } else if (grepl("^[0-9]+$", age_value)) {
    # If it's a specific value, return the age value as integer
    return(as.numeric(age_value))
  } else if (grepl("^[0-9]+\\+$", age_value)) {
    # If the age value ends with '+', return the numeric part
    return(as.numeric(str_remove(age_value, "\\+")))
  } else {
    # If it's not a valid range, specific value, or '36+', return NA
    return(NA)
  }
}
print(behavior[0:10,"Age"])

##  [1] "22-25" "26-30" "26-30" "31-35" "26-30" "31-35" "22-25" "31-35" "26-30"
## [10] "26-30"

# Apply the function to the Age column
behavior$Age <- sapply(behavior$Age, calculate_average_age)

# Print the modified data frame
print(behavior[0:10,"Age"])

##  [1] 24 28 28 33 28 33 24 33 28 28

sex <- ifelse(behavior[id_list,"Gender"] == "F", 0, 1)
age <- as.numeric(behavior[id_list,"Age"])
print(length(sex))

## [1] 440

print(length(age))

## [1] 440

• A list (net) of one or more vectors is created for network(s) of interest (e.g., net_7 indicates vertex membership in the default mode network)

net_data <- read_cifti("./data/Schaefer2018_1000Parcels_7Networks_order.dlabel.nii")

## Warning in read_cifti_convert(cifti_fname, surfL_fname = surfL_fname, surfR_fname = surfR_fname, : Only the following brainstructures are present in the CIFTI file: left, right

# names(net$data)
parcel_1000 <- t(rbind(net_data$data$cortex_left, net_data$data$cortex_right))

parcel_labels <- as.list(rownames(net_data$meta$cifti$labels$parcels))
print(parcel_labels)

## [[1]]
## [1] "???"
## 
## [[2]]
## [1] "7Networks_LH_Vis_1"
## 
## [[3]]
## [1] "7Networks_LH_Vis_2"
## 
## [[4]]
## [1] "7Networks_LH_Vis_3"
## 
## [[5]]
## [1] "7Networks_LH_Vis_4"
## 
## [[6]]
## [1] "7Networks_LH_Vis_5"
## 
## [[7]]
## [1] "7Networks_LH_Vis_6"
## 
## [[8]]
## [1] "7Networks_LH_Vis_7"
## 
## [[9]]
## [1] "7Networks_LH_Vis_8"
## 
## [[10]]
## [1] "7Networks_LH_Vis_9"
## 
## [[11]]
## [1] "7Networks_LH_Vis_10"
## 
## [[12]]
## [1] "7Networks_LH_Vis_11"
## 
## [[13]]
## [1] "7Networks_LH_Vis_12"
## 
## [[14]]
## [1] "7Networks_LH_Vis_13"
## 
## [[15]]
## [1] "7Networks_LH_Vis_14"
## 
## [[16]]
## [1] "7Networks_LH_Vis_15"
## 
## [[17]]
## [1] "7Networks_LH_Vis_16"
## 
## [[18]]
## [1] "7Networks_LH_Vis_17"
## 
## [[19]]
## [1] "7Networks_LH_Vis_18"
## 
## [[20]]
## [1] "7Networks_LH_Vis_19"
## 
## [[21]]
## [1] "7Networks_LH_Vis_20"
## 
## [[22]]
## [1] "7Networks_LH_Vis_21"
## 
## [[23]]
## [1] "7Networks_LH_Vis_22"
## 
## [[24]]
## [1] "7Networks_LH_Vis_23"
## 
## [[25]]
## [1] "7Networks_LH_Vis_24"
## 
## [[26]]
## [1] "7Networks_LH_Vis_25"
## 
## [[27]]
## [1] "7Networks_LH_Vis_26"
## 
## [[28]]
## [1] "7Networks_LH_Vis_27"
## 
## [[29]]
## [1] "7Networks_LH_Vis_28"
## 
## [[30]]
## [1] "7Networks_LH_Vis_29"
## 
## [[31]]
## [1] "7Networks_LH_Vis_30"
## 
## [[32]]
## [1] "7Networks_LH_Vis_31"
## 
## [[33]]
## [1] "7Networks_LH_Vis_32"
## 
## [[34]]
## [1] "7Networks_LH_Vis_33"
## 
## [[35]]
## [1] "7Networks_LH_Vis_34"
## 
## [[36]]
## [1] "7Networks_LH_Vis_35"
## 
## [[37]]
## [1] "7Networks_LH_Vis_36"
## 
## [[38]]
## [1] "7Networks_LH_Vis_37"
## 
## [[39]]
## [1] "7Networks_LH_Vis_38"
## 
## [[40]]
## [1] "7Networks_LH_Vis_39"
## 
## [[41]]
## [1] "7Networks_LH_Vis_40"
## 
## [[42]]
## [1] "7Networks_LH_Vis_41"
## 
## [[43]]
## [1] "7Networks_LH_Vis_42"
## 
## [[44]]
## [1] "7Networks_LH_Vis_43"
## 
## [[45]]
## [1] "7Networks_LH_Vis_44"
## 
## [[46]]
## [1] "7Networks_LH_Vis_45"
## 
## [[47]]
## [1] "7Networks_LH_Vis_46"
## 
## [[48]]
## [1] "7Networks_LH_Vis_47"
## 
## [[49]]
## [1] "7Networks_LH_Vis_48"
## 
## [[50]]
## [1] "7Networks_LH_Vis_49"
## 
## [[51]]
## [1] "7Networks_LH_Vis_50"
## 
## [[52]]
## [1] "7Networks_LH_Vis_51"
## 
## [[53]]
## [1] "7Networks_LH_Vis_52"
## 
## [[54]]
## [1] "7Networks_LH_Vis_53"
## 
## [[55]]
## [1] "7Networks_LH_Vis_54"
## 
## [[56]]
## [1] "7Networks_LH_Vis_55"
## 
## [[57]]
## [1] "7Networks_LH_Vis_56"
## 
## [[58]]
## [1] "7Networks_LH_Vis_57"
## 
## [[59]]
## [1] "7Networks_LH_Vis_58"
## 
## [[60]]
## [1] "7Networks_LH_Vis_59"
## 
## [[61]]
## [1] "7Networks_LH_Vis_60"
## 
## [[62]]
## [1] "7Networks_LH_Vis_61"
## 
## [[63]]
## [1] "7Networks_LH_Vis_62"
## 
## [[64]]
## [1] "7Networks_LH_Vis_63"
## 
## [[65]]
## [1] "7Networks_LH_Vis_64"
## 
## [[66]]
## [1] "7Networks_LH_Vis_65"
## 
## [[67]]
## [1] "7Networks_LH_Vis_66"
## 
## [[68]]
## [1] "7Networks_LH_Vis_67"
## 
## [[69]]
## [1] "7Networks_LH_Vis_68"
## 
## [[70]]
## [1] "7Networks_LH_Vis_69"
## 
## [[71]]
## [1] "7Networks_LH_Vis_70"
## 
## [[72]]
## [1] "7Networks_LH_Vis_71"
## 
## [[73]]
## [1] "7Networks_LH_Vis_72"
## 
## [[74]]
## [1] "7Networks_LH_Vis_73"
## 
## [[75]]
## [1] "7Networks_LH_Vis_74"
## 
## [[76]]
## [1] "7Networks_LH_Vis_75"
## 
## [[77]]
## [1] "7Networks_LH_Vis_76"
## 
## [[78]]
## [1] "7Networks_LH_Vis_77"
## 
## [[79]]
## [1] "7Networks_LH_Vis_78"
## 
## [[80]]
## [1] "7Networks_LH_Vis_79"
## 
## [[81]]
## [1] "7Networks_LH_Vis_80"
## 
## [[82]]
## [1] "7Networks_LH_Vis_81"
## 
## [[83]]
## [1] "7Networks_LH_SomMot_1"
## 
## [[84]]
## [1] "7Networks_LH_SomMot_2"
## 
## [[85]]
## [1] "7Networks_LH_SomMot_3"
## 
## [[86]]
## [1] "7Networks_LH_SomMot_4"
## 
## [[87]]
## [1] "7Networks_LH_SomMot_5"
## 
## [[88]]
## [1] "7Networks_LH_SomMot_6"
## 
## [[89]]
## [1] "7Networks_LH_SomMot_7"
## 
## [[90]]
## [1] "7Networks_LH_SomMot_8"
## 
## [[91]]
## [1] "7Networks_LH_SomMot_9"
## 
## [[92]]
## [1] "7Networks_LH_SomMot_10"
## 
## [[93]]
## [1] "7Networks_LH_SomMot_11"
## 
## [[94]]
## [1] "7Networks_LH_SomMot_12"
## 
## [[95]]
## [1] "7Networks_LH_SomMot_13"
## 
## [[96]]
## [1] "7Networks_LH_SomMot_14"
## 
## [[97]]
## [1] "7Networks_LH_SomMot_15"
## 
## [[98]]
## [1] "7Networks_LH_SomMot_16"
## 
## [[99]]
## [1] "7Networks_LH_SomMot_17"
## 
## [[100]]
## [1] "7Networks_LH_SomMot_18"
## 
## [[101]]
## [1] "7Networks_LH_SomMot_19"
## 
## [[102]]
## [1] "7Networks_LH_SomMot_20"
## 
## [[103]]
## [1] "7Networks_LH_SomMot_21"
## 
## [[104]]
## [1] "7Networks_LH_SomMot_22"
## 
## [[105]]
## [1] "7Networks_LH_SomMot_23"
## 
## [[106]]
## [1] "7Networks_LH_SomMot_24"
## 
## [[107]]
## [1] "7Networks_LH_SomMot_25"
## 
## [[108]]
## [1] "7Networks_LH_SomMot_26"
## 
## [[109]]
## [1] "7Networks_LH_SomMot_27"
## 
## [[110]]
## [1] "7Networks_LH_SomMot_28"
## 
## [[111]]
## [1] "7Networks_LH_SomMot_29"
## 
## [[112]]
## [1] "7Networks_LH_SomMot_30"
## 
## [[113]]
## [1] "7Networks_LH_SomMot_31"
## 
## [[114]]
## [1] "7Networks_LH_SomMot_32"
## 
## [[115]]
## [1] "7Networks_LH_SomMot_33"
## 
## [[116]]
## [1] "7Networks_LH_SomMot_34"
## 
## [[117]]
## [1] "7Networks_LH_SomMot_35"
## 
## [[118]]
## [1] "7Networks_LH_SomMot_36"
## 
## [[119]]
## [1] "7Networks_LH_SomMot_37"
## 
## [[120]]
## [1] "7Networks_LH_SomMot_38"
## 
## [[121]]
## [1] "7Networks_LH_SomMot_39"
## 
## [[122]]
## [1] "7Networks_LH_SomMot_40"
## 
## [[123]]
## [1] "7Networks_LH_SomMot_41"
## 
## [[124]]
## [1] "7Networks_LH_SomMot_42"
## 
## [[125]]
## [1] "7Networks_LH_SomMot_43"
## 
## [[126]]
## [1] "7Networks_LH_SomMot_44"
## 
## [[127]]
## [1] "7Networks_LH_SomMot_45"
## 
## [[128]]
## [1] "7Networks_LH_SomMot_46"
## 
## [[129]]
## [1] "7Networks_LH_SomMot_47"
## 
## [[130]]
## [1] "7Networks_LH_SomMot_48"
## 
## [[131]]
## [1] "7Networks_LH_SomMot_49"
## 
## [[132]]
## [1] "7Networks_LH_SomMot_50"
## 
## [[133]]
## [1] "7Networks_LH_SomMot_51"
## 
## [[134]]
## [1] "7Networks_LH_SomMot_52"
## 
## [[135]]
## [1] "7Networks_LH_SomMot_53"
## 
## [[136]]
## [1] "7Networks_LH_SomMot_54"
## 
## [[137]]
## [1] "7Networks_LH_SomMot_55"
## 
## [[138]]
## [1] "7Networks_LH_SomMot_56"
## 
## [[139]]
## [1] "7Networks_LH_SomMot_57"
## 
## [[140]]
## [1] "7Networks_LH_SomMot_58"
## 
## [[141]]
## [1] "7Networks_LH_SomMot_59"
## 
## [[142]]
## [1] "7Networks_LH_SomMot_60"
## 
## [[143]]
## [1] "7Networks_LH_SomMot_61"
## 
## [[144]]
## [1] "7Networks_LH_SomMot_62"
## 
## [[145]]
## [1] "7Networks_LH_SomMot_63"
## 
## [[146]]
## [1] "7Networks_LH_SomMot_64"
## 
## [[147]]
## [1] "7Networks_LH_SomMot_65"
## 
## [[148]]
## [1] "7Networks_LH_SomMot_66"
## 
## [[149]]
## [1] "7Networks_LH_SomMot_67"
## 
## [[150]]
## [1] "7Networks_LH_SomMot_68"
## 
## [[151]]
## [1] "7Networks_LH_SomMot_69"
## 
## [[152]]
## [1] "7Networks_LH_SomMot_70"
## 
## [[153]]
## [1] "7Networks_LH_SomMot_71"
## 
## [[154]]
## [1] "7Networks_LH_SomMot_72"
## 
## [[155]]
## [1] "7Networks_LH_SomMot_73"
## 
## [[156]]
## [1] "7Networks_LH_SomMot_74"
## 
## [[157]]
## [1] "7Networks_LH_SomMot_75"
## 
## [[158]]
## [1] "7Networks_LH_SomMot_76"
## 
## [[159]]
## [1] "7Networks_LH_SomMot_77"
## 
## [[160]]
## [1] "7Networks_LH_SomMot_78"
## 
## [[161]]
## [1] "7Networks_LH_SomMot_79"
## 
## [[162]]
## [1] "7Networks_LH_SomMot_80"
## 
## [[163]]
## [1] "7Networks_LH_SomMot_81"
## 
## [[164]]
## [1] "7Networks_LH_SomMot_82"
## 
## [[165]]
## [1] "7Networks_LH_SomMot_83"
## 
## [[166]]
## [1] "7Networks_LH_SomMot_84"
## 
## [[167]]
## [1] "7Networks_LH_SomMot_85"
## 
## [[168]]
## [1] "7Networks_LH_SomMot_86"
## 
## [[169]]
## [1] "7Networks_LH_SomMot_87"
## 
## [[170]]
## [1] "7Networks_LH_SomMot_88"
## 
## [[171]]
## [1] "7Networks_LH_SomMot_89"
## 
## [[172]]
## [1] "7Networks_LH_SomMot_90"
## 
## [[173]]
## [1] "7Networks_LH_SomMot_91"
## 
## [[174]]
## [1] "7Networks_LH_DorsAttn_Post_1"
## 
## [[175]]
## [1] "7Networks_LH_DorsAttn_Post_2"
## 
## [[176]]
## [1] "7Networks_LH_DorsAttn_Post_3"
## 
## [[177]]
## [1] "7Networks_LH_DorsAttn_Post_4"
## 
## [[178]]
## [1] "7Networks_LH_DorsAttn_Post_5"
## 
## [[179]]
## [1] "7Networks_LH_DorsAttn_Post_6"
## 
## [[180]]
## [1] "7Networks_LH_DorsAttn_Post_7"
## 
## [[181]]
## [1] "7Networks_LH_DorsAttn_Post_8"
## 
## [[182]]
## [1] "7Networks_LH_DorsAttn_Post_9"
## 
## [[183]]
## [1] "7Networks_LH_DorsAttn_Post_10"
## 
## [[184]]
## [1] "7Networks_LH_DorsAttn_Post_11"
## 
## [[185]]
## [1] "7Networks_LH_DorsAttn_Post_12"
## 
## [[186]]
## [1] "7Networks_LH_DorsAttn_Post_13"
## 
## [[187]]
## [1] "7Networks_LH_DorsAttn_Post_14"
## 
## [[188]]
## [1] "7Networks_LH_DorsAttn_Post_15"
## 
## [[189]]
## [1] "7Networks_LH_DorsAttn_Post_16"
## 
## [[190]]
## [1] "7Networks_LH_DorsAttn_Post_17"
## 
## [[191]]
## [1] "7Networks_LH_DorsAttn_Post_18"
## 
## [[192]]
## [1] "7Networks_LH_DorsAttn_Post_19"
## 
## [[193]]
## [1] "7Networks_LH_DorsAttn_Post_20"
## 
## [[194]]
## [1] "7Networks_LH_DorsAttn_Post_21"
## 
## [[195]]
## [1] "7Networks_LH_DorsAttn_Post_22"
## 
## [[196]]
## [1] "7Networks_LH_DorsAttn_Post_23"
## 
## [[197]]
## [1] "7Networks_LH_DorsAttn_Post_24"
## 
## [[198]]
## [1] "7Networks_LH_DorsAttn_Post_25"
## 
## [[199]]
## [1] "7Networks_LH_DorsAttn_Post_26"
## 
## [[200]]
## [1] "7Networks_LH_DorsAttn_Post_27"
## 
## [[201]]
## [1] "7Networks_LH_DorsAttn_Post_28"
## 
## [[202]]
## [1] "7Networks_LH_DorsAttn_Post_29"
## 
## [[203]]
## [1] "7Networks_LH_DorsAttn_Post_30"
## 
## [[204]]
## [1] "7Networks_LH_DorsAttn_Post_31"
## 
## [[205]]
## [1] "7Networks_LH_DorsAttn_Post_32"
## 
## [[206]]
## [1] "7Networks_LH_DorsAttn_Post_33"
## 
## [[207]]
## [1] "7Networks_LH_DorsAttn_Post_34"
## 
## [[208]]
## [1] "7Networks_LH_DorsAttn_Post_35"
## 
## [[209]]
## [1] "7Networks_LH_DorsAttn_Post_36"
## 
## [[210]]
## [1] "7Networks_LH_DorsAttn_Post_37"
## 
## [[211]]
## [1] "7Networks_LH_DorsAttn_Post_38"
## 
## [[212]]
## [1] "7Networks_LH_DorsAttn_Post_39"
## 
## [[213]]
## [1] "7Networks_LH_DorsAttn_Post_40"
## 
## [[214]]
## [1] "7Networks_LH_DorsAttn_Post_41"
## 
## [[215]]
## [1] "7Networks_LH_DorsAttn_Post_42"
## 
## [[216]]
## [1] "7Networks_LH_DorsAttn_Post_43"
## 
## [[217]]
## [1] "7Networks_LH_DorsAttn_Post_44"
## 
## [[218]]
## [1] "7Networks_LH_DorsAttn_Post_45"
## 
## [[219]]
## [1] "7Networks_LH_DorsAttn_Post_46"
## 
## [[220]]
## [1] "7Networks_LH_DorsAttn_Post_47"
## 
## [[221]]
## [1] "7Networks_LH_DorsAttn_Post_48"
## 
## [[222]]
## [1] "7Networks_LH_DorsAttn_Post_49"
## 
## [[223]]
## [1] "7Networks_LH_DorsAttn_Post_50"
## 
## [[224]]
## [1] "7Networks_LH_DorsAttn_FEF_1"
## 
## [[225]]
## [1] "7Networks_LH_DorsAttn_FEF_2"
## 
## [[226]]
## [1] "7Networks_LH_DorsAttn_FEF_3"
## 
## [[227]]
## [1] "7Networks_LH_DorsAttn_FEF_4"
## 
## [[228]]
## [1] "7Networks_LH_DorsAttn_FEF_5"
## 
## [[229]]
## [1] "7Networks_LH_DorsAttn_FEF_6"
## 
## [[230]]
## [1] "7Networks_LH_DorsAttn_FEF_7"
## 
## [[231]]
## [1] "7Networks_LH_DorsAttn_PrCv_1"
## 
## [[232]]
## [1] "7Networks_LH_DorsAttn_PrCv_2"
## 
## [[233]]
## [1] "7Networks_LH_DorsAttn_PrCv_3"
## 
## [[234]]
## [1] "7Networks_LH_DorsAttn_PrCv_4"
## 
## [[235]]
## [1] "7Networks_LH_SalVentAttn_ParOper_1"
## 
## [[236]]
## [1] "7Networks_LH_SalVentAttn_ParOper_2"
## 
## [[237]]
## [1] "7Networks_LH_SalVentAttn_ParOper_3"
## 
## [[238]]
## [1] "7Networks_LH_SalVentAttn_ParOper_4"
## 
## [[239]]
## [1] "7Networks_LH_SalVentAttn_ParOper_5"
## 
## [[240]]
## [1] "7Networks_LH_SalVentAttn_ParOper_6"
## 
## [[241]]
## [1] "7Networks_LH_SalVentAttn_ParOper_7"
## 
## [[242]]
## [1] "7Networks_LH_SalVentAttn_ParOper_8"
## 
## [[243]]
## [1] "7Networks_LH_SalVentAttn_ParOper_9"
## 
## [[244]]
## [1] "7Networks_LH_SalVentAttn_TempOcc_1"
## 
## [[245]]
## [1] "7Networks_LH_SalVentAttn_TempOcc_2"
## 
## [[246]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_1"
## 
## [[247]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_2"
## 
## [[248]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_3"
## 
## [[249]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_4"
## 
## [[250]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_5"
## 
## [[251]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_6"
## 
## [[252]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_7"
## 
## [[253]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_8"
## 
## [[254]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_9"
## 
## [[255]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_10"
## 
## [[256]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_11"
## 
## [[257]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_12"
## 
## [[258]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_13"
## 
## [[259]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_14"
## 
## [[260]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_15"
## 
## [[261]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_16"
## 
## [[262]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_17"
## 
## [[263]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_18"
## 
## [[264]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_19"
## 
## [[265]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_20"
## 
## [[266]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_21"
## 
## [[267]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_22"
## 
## [[268]]
## [1] "7Networks_LH_SalVentAttn_FrOperIns_23"
## 
## [[269]]
## [1] "7Networks_LH_SalVentAttn_PFCl_1"
## 
## [[270]]
## [1] "7Networks_LH_SalVentAttn_PFCl_2"
## 
## [[271]]
## [1] "7Networks_LH_SalVentAttn_Med_1"
## 
## [[272]]
## [1] "7Networks_LH_SalVentAttn_Med_2"
## 
## [[273]]
## [1] "7Networks_LH_SalVentAttn_Med_3"
## 
## [[274]]
## [1] "7Networks_LH_SalVentAttn_Med_4"
## 
## [[275]]
## [1] "7Networks_LH_SalVentAttn_Med_5"
## 
## [[276]]
## [1] "7Networks_LH_SalVentAttn_Med_6"
## 
## [[277]]
## [1] "7Networks_LH_SalVentAttn_Med_7"
## 
## [[278]]
## [1] "7Networks_LH_SalVentAttn_Med_8"
## 
## [[279]]
## [1] "7Networks_LH_SalVentAttn_Med_9"
## 
## [[280]]
## [1] "7Networks_LH_SalVentAttn_Med_10"
## 
## [[281]]
## [1] "7Networks_LH_SalVentAttn_Med_11"
## 
## [[282]]
## [1] "7Networks_LH_SalVentAttn_Med_12"
## 
## [[283]]
## [1] "7Networks_LH_SalVentAttn_Med_13"
## 
## [[284]]
## [1] "7Networks_LH_SalVentAttn_Med_14"
## 
## [[285]]
## [1] "7Networks_LH_SalVentAttn_Med_15"
## 
## [[286]]
## [1] "7Networks_LH_SalVentAttn_Med_16"
## 
## [[287]]
## [1] "7Networks_LH_SalVentAttn_Med_17"
## 
## [[288]]
## [1] "7Networks_LH_SalVentAttn_Med_18"
## 
## [[289]]
## [1] "7Networks_LH_SalVentAttn_Med_19"
## 
## [[290]]
## [1] "7Networks_LH_Limbic_OFC_1"
## 
## [[291]]
## [1] "7Networks_LH_Limbic_OFC_2"
## 
## [[292]]
## [1] "7Networks_LH_Limbic_OFC_3"
## 
## [[293]]
## [1] "7Networks_LH_Limbic_OFC_4"
## 
## [[294]]
## [1] "7Networks_LH_Limbic_OFC_5"
## 
## [[295]]
## [1] "7Networks_LH_Limbic_OFC_6"
## 
## [[296]]
## [1] "7Networks_LH_Limbic_OFC_7"
## 
## [[297]]
## [1] "7Networks_LH_Limbic_OFC_8"
## 
## [[298]]
## [1] "7Networks_LH_Limbic_OFC_9"
## 
## [[299]]
## [1] "7Networks_LH_Limbic_OFC_10"
## 
## [[300]]
## [1] "7Networks_LH_Limbic_OFC_11"
## 
## [[301]]
## [1] "7Networks_LH_Limbic_OFC_12"
## 
## [[302]]
## [1] "7Networks_LH_Limbic_OFC_13"
## 
## [[303]]
## [1] "7Networks_LH_Limbic_OFC_14"
## 
## [[304]]
## [1] "7Networks_LH_Limbic_TempPole_1"
## 
## [[305]]
## [1] "7Networks_LH_Limbic_TempPole_2"
## 
## [[306]]
## [1] "7Networks_LH_Limbic_TempPole_3"
## 
## [[307]]
## [1] "7Networks_LH_Limbic_TempPole_4"
## 
## [[308]]
## [1] "7Networks_LH_Limbic_TempPole_5"
## 
## [[309]]
## [1] "7Networks_LH_Limbic_TempPole_6"
## 
## [[310]]
## [1] "7Networks_LH_Limbic_TempPole_7"
## 
## [[311]]
## [1] "7Networks_LH_Limbic_TempPole_8"
## 
## [[312]]
## [1] "7Networks_LH_Limbic_TempPole_9"
## 
## [[313]]
## [1] "7Networks_LH_Limbic_TempPole_10"
## 
## [[314]]
## [1] "7Networks_LH_Limbic_TempPole_11"
## 
## [[315]]
## [1] "7Networks_LH_Limbic_TempPole_12"
## 
## [[316]]
## [1] "7Networks_LH_Limbic_TempPole_13"
## 
## [[317]]
## [1] "7Networks_LH_Limbic_TempPole_14"
## 
## [[318]]
## [1] "7Networks_LH_Limbic_TempPole_15"
## 
## [[319]]
## [1] "7Networks_LH_Cont_Par_1"
## 
## [[320]]
## [1] "7Networks_LH_Cont_Par_2"
## 
## [[321]]
## [1] "7Networks_LH_Cont_Par_3"
## 
## [[322]]
## [1] "7Networks_LH_Cont_Par_4"
## 
## [[323]]
## [1] "7Networks_LH_Cont_Par_5"
## 
## [[324]]
## [1] "7Networks_LH_Cont_Par_6"
## 
## [[325]]
## [1] "7Networks_LH_Cont_Par_7"
## 
## [[326]]
## [1] "7Networks_LH_Cont_Par_8"
## 
## [[327]]
## [1] "7Networks_LH_Cont_Par_9"
## 
## [[328]]
## [1] "7Networks_LH_Cont_Par_10"
## 
## [[329]]
## [1] "7Networks_LH_Cont_Par_11"
## 
## [[330]]
## [1] "7Networks_LH_Cont_Par_12"
## 
## [[331]]
## [1] "7Networks_LH_Cont_Par_13"
## 
## [[332]]
## [1] "7Networks_LH_Cont_Par_14"
## 
## [[333]]
## [1] "7Networks_LH_Cont_Par_15"
## 
## [[334]]
## [1] "7Networks_LH_Cont_Temp_1"
## 
## [[335]]
## [1] "7Networks_LH_Cont_Temp_2"
## 
## [[336]]
## [1] "7Networks_LH_Cont_Temp_3"
## 
## [[337]]
## [1] "7Networks_LH_Cont_Temp_4"
## 
## [[338]]
## [1] "7Networks_LH_Cont_PFCd_1"
## 
## [[339]]
## [1] "7Networks_LH_Cont_PFCl_1"
## 
## [[340]]
## [1] "7Networks_LH_Cont_PFCl_2"
## 
## [[341]]
## [1] "7Networks_LH_Cont_PFCl_3"
## 
## [[342]]
## [1] "7Networks_LH_Cont_PFCl_4"
## 
## [[343]]
## [1] "7Networks_LH_Cont_PFCl_5"
## 
## [[344]]
## [1] "7Networks_LH_Cont_PFCl_6"
## 
## [[345]]
## [1] "7Networks_LH_Cont_PFCl_7"
## 
## [[346]]
## [1] "7Networks_LH_Cont_PFCl_8"
## 
## [[347]]
## [1] "7Networks_LH_Cont_PFCl_9"
## 
## [[348]]
## [1] "7Networks_LH_Cont_PFCl_10"
## 
## [[349]]
## [1] "7Networks_LH_Cont_PFCl_11"
## 
## [[350]]
## [1] "7Networks_LH_Cont_PFCl_12"
## 
## [[351]]
## [1] "7Networks_LH_Cont_PFCl_13"
## 
## [[352]]
## [1] "7Networks_LH_Cont_PFCl_14"
## 
## [[353]]
## [1] "7Networks_LH_Cont_PFCl_15"
## 
## [[354]]
## [1] "7Networks_LH_Cont_PFCl_16"
## 
## [[355]]
## [1] "7Networks_LH_Cont_PFCl_17"
## 
## [[356]]
## [1] "7Networks_LH_Cont_PFCl_18"
## 
## [[357]]
## [1] "7Networks_LH_Cont_PFCl_19"
## 
## [[358]]
## [1] "7Networks_LH_Cont_PFCl_20"
## 
## [[359]]
## [1] "7Networks_LH_Cont_OFC_1"
## 
## [[360]]
## [1] "7Networks_LH_Cont_PFCv_1"
## 
## [[361]]
## [1] "7Networks_LH_Cont_PFCv_2"
## 
## [[362]]
## [1] "7Networks_LH_Cont_pCun_1"
## 
## [[363]]
## [1] "7Networks_LH_Cont_pCun_2"
## 
## [[364]]
## [1] "7Networks_LH_Cont_pCun_3"
## 
## [[365]]
## [1] "7Networks_LH_Cont_pCun_4"
## 
## [[366]]
## [1] "7Networks_LH_Cont_Cing_1"
## 
## [[367]]
## [1] "7Networks_LH_Cont_Cing_2"
## 
## [[368]]
## [1] "7Networks_LH_Cont_Cing_3"
## 
## [[369]]
## [1] "7Networks_LH_Cont_Cing_4"
## 
## [[370]]
## [1] "7Networks_LH_Cont_Cing_5"
## 
## [[371]]
## [1] "7Networks_LH_Cont_Cing_6"
## 
## [[372]]
## [1] "7Networks_LH_Cont_Cing_7"
## 
## [[373]]
## [1] "7Networks_LH_Cont_Cing_8"
## 
## [[374]]
## [1] "7Networks_LH_Cont_PFCmp_1"
## 
## [[375]]
## [1] "7Networks_LH_Cont_PFCmp_2"
## 
## [[376]]
## [1] "7Networks_LH_Default_Par_1"
## 
## [[377]]
## [1] "7Networks_LH_Default_Par_2"
## 
## [[378]]
## [1] "7Networks_LH_Default_Par_3"
## 
## [[379]]
## [1] "7Networks_LH_Default_Par_4"
## 
## [[380]]
## [1] "7Networks_LH_Default_Par_5"
## 
## [[381]]
## [1] "7Networks_LH_Default_Par_6"
## 
## [[382]]
## [1] "7Networks_LH_Default_Par_7"
## 
## [[383]]
## [1] "7Networks_LH_Default_Par_8"
## 
## [[384]]
## [1] "7Networks_LH_Default_Par_9"
## 
## [[385]]
## [1] "7Networks_LH_Default_Par_10"
## 
## [[386]]
## [1] "7Networks_LH_Default_Par_11"
## 
## [[387]]
## [1] "7Networks_LH_Default_Par_12"
## 
## [[388]]
## [1] "7Networks_LH_Default_Par_13"
## 
## [[389]]
## [1] "7Networks_LH_Default_Par_14"
## 
## [[390]]
## [1] "7Networks_LH_Default_Par_15"
## 
## [[391]]
## [1] "7Networks_LH_Default_Par_16"
## 
## [[392]]
## [1] "7Networks_LH_Default_Par_17"
## 
## [[393]]
## [1] "7Networks_LH_Default_Par_18"
## 
## [[394]]
## [1] "7Networks_LH_Default_Par_19"
## 
## [[395]]
## [1] "7Networks_LH_Default_Temp_1"
## 
## [[396]]
## [1] "7Networks_LH_Default_Temp_2"
## 
## [[397]]
## [1] "7Networks_LH_Default_Temp_3"
## 
## [[398]]
## [1] "7Networks_LH_Default_Temp_4"
## 
## [[399]]
## [1] "7Networks_LH_Default_Temp_5"
## 
## [[400]]
## [1] "7Networks_LH_Default_Temp_6"
## 
## [[401]]
## [1] "7Networks_LH_Default_Temp_7"
## 
## [[402]]
## [1] "7Networks_LH_Default_Temp_8"
## 
## [[403]]
## [1] "7Networks_LH_Default_Temp_9"
## 
## [[404]]
## [1] "7Networks_LH_Default_Temp_10"
## 
## [[405]]
## [1] "7Networks_LH_Default_Temp_11"
## 
## [[406]]
## [1] "7Networks_LH_Default_Temp_12"
## 
## [[407]]
## [1] "7Networks_LH_Default_Temp_13"
## 
## [[408]]
## [1] "7Networks_LH_Default_Temp_14"
## 
## [[409]]
## [1] "7Networks_LH_Default_Temp_15"
## 
## [[410]]
## [1] "7Networks_LH_Default_Temp_16"
## 
## [[411]]
## [1] "7Networks_LH_Default_Temp_17"
## 
## [[412]]
## [1] "7Networks_LH_Default_Temp_18"
## 
## [[413]]
## [1] "7Networks_LH_Default_Temp_19"
## 
## [[414]]
## [1] "7Networks_LH_Default_Temp_20"
## 
## [[415]]
## [1] "7Networks_LH_Default_Temp_21"
## 
## [[416]]
## [1] "7Networks_LH_Default_Temp_22"
## 
## [[417]]
## [1] "7Networks_LH_Default_PFC_1"
## 
## [[418]]
## [1] "7Networks_LH_Default_PFC_2"
## 
## [[419]]
## [1] "7Networks_LH_Default_PFC_3"
## 
## [[420]]
## [1] "7Networks_LH_Default_PFC_4"
## 
## [[421]]
## [1] "7Networks_LH_Default_PFC_5"
## 
## [[422]]
## [1] "7Networks_LH_Default_PFC_6"
## 
## [[423]]
## [1] "7Networks_LH_Default_PFC_7"
## 
## [[424]]
## [1] "7Networks_LH_Default_PFC_8"
## 
## [[425]]
## [1] "7Networks_LH_Default_PFC_9"
## 
## [[426]]
## [1] "7Networks_LH_Default_PFC_10"
## 
## [[427]]
## [1] "7Networks_LH_Default_PFC_11"
## 
## [[428]]
## [1] "7Networks_LH_Default_PFC_12"
## 
## [[429]]
## [1] "7Networks_LH_Default_PFC_13"
## 
## [[430]]
## [1] "7Networks_LH_Default_PFC_14"
## 
## [[431]]
## [1] "7Networks_LH_Default_PFC_15"
## 
## [[432]]
## [1] "7Networks_LH_Default_PFC_16"
## 
## [[433]]
## [1] "7Networks_LH_Default_PFC_17"
## 
## [[434]]
## [1] "7Networks_LH_Default_PFC_18"
## 
## [[435]]
## [1] "7Networks_LH_Default_PFC_19"
## 
## [[436]]
## [1] "7Networks_LH_Default_PFC_20"
## 
## [[437]]
## [1] "7Networks_LH_Default_PFC_21"
## 
## [[438]]
## [1] "7Networks_LH_Default_PFC_22"
## 
## [[439]]
## [1] "7Networks_LH_Default_PFC_23"
## 
## [[440]]
## [1] "7Networks_LH_Default_PFC_24"
## 
## [[441]]
## [1] "7Networks_LH_Default_PFC_25"
## 
## [[442]]
## [1] "7Networks_LH_Default_PFC_26"
## 
## [[443]]
## [1] "7Networks_LH_Default_PFC_27"
## 
## [[444]]
## [1] "7Networks_LH_Default_PFC_28"
## 
## [[445]]
## [1] "7Networks_LH_Default_PFC_29"
## 
## [[446]]
## [1] "7Networks_LH_Default_PFC_30"
## 
## [[447]]
## [1] "7Networks_LH_Default_PFC_31"
## 
## [[448]]
## [1] "7Networks_LH_Default_PFC_32"
## 
## [[449]]
## [1] "7Networks_LH_Default_PFC_33"
## 
## [[450]]
## [1] "7Networks_LH_Default_PFC_34"
## 
## [[451]]
## [1] "7Networks_LH_Default_PFC_35"
## 
## [[452]]
## [1] "7Networks_LH_Default_PFC_36"
## 
## [[453]]
## [1] "7Networks_LH_Default_PFC_37"
## 
## [[454]]
## [1] "7Networks_LH_Default_PFC_38"
## 
## [[455]]
## [1] "7Networks_LH_Default_PFC_39"
## 
## [[456]]
## [1] "7Networks_LH_Default_PFC_40"
## 
## [[457]]
## [1] "7Networks_LH_Default_PFC_41"
## 
## [[458]]
## [1] "7Networks_LH_Default_PFC_42"
## 
## [[459]]
## [1] "7Networks_LH_Default_PFC_43"
## 
## [[460]]
## [1] "7Networks_LH_Default_PFC_44"
## 
## [[461]]
## [1] "7Networks_LH_Default_PFC_45"
## 
## [[462]]
## [1] "7Networks_LH_Default_PFC_46"
## 
## [[463]]
## [1] "7Networks_LH_Default_PFC_47"
## 
## [[464]]
## [1] "7Networks_LH_Default_PFC_48"
## 
## [[465]]
## [1] "7Networks_LH_Default_PFC_49"
## 
## [[466]]
## [1] "7Networks_LH_Default_PFC_50"
## 
## [[467]]
## [1] "7Networks_LH_Default_pCunPCC_1"
## 
## [[468]]
## [1] "7Networks_LH_Default_pCunPCC_2"
## 
## [[469]]
## [1] "7Networks_LH_Default_pCunPCC_3"
## 
## [[470]]
## [1] "7Networks_LH_Default_pCunPCC_4"
## 
## [[471]]
## [1] "7Networks_LH_Default_pCunPCC_5"
## 
## [[472]]
## [1] "7Networks_LH_Default_pCunPCC_6"
## 
## [[473]]
## [1] "7Networks_LH_Default_pCunPCC_7"
## 
## [[474]]
## [1] "7Networks_LH_Default_pCunPCC_8"
## 
## [[475]]
## [1] "7Networks_LH_Default_pCunPCC_9"
## 
## [[476]]
## [1] "7Networks_LH_Default_pCunPCC_10"
## 
## [[477]]
## [1] "7Networks_LH_Default_pCunPCC_11"
## 
## [[478]]
## [1] "7Networks_LH_Default_pCunPCC_12"
## 
## [[479]]
## [1] "7Networks_LH_Default_pCunPCC_13"
## 
## [[480]]
## [1] "7Networks_LH_Default_pCunPCC_14"
## 
## [[481]]
## [1] "7Networks_LH_Default_pCunPCC_15"
## 
## [[482]]
## [1] "7Networks_LH_Default_pCunPCC_16"
## 
## [[483]]
## [1] "7Networks_LH_Default_pCunPCC_17"
## 
## [[484]]
## [1] "7Networks_LH_Default_pCunPCC_18"
## 
## [[485]]
## [1] "7Networks_LH_Default_pCunPCC_19"
## 
## [[486]]
## [1] "7Networks_LH_Default_pCunPCC_20"
## 
## [[487]]
## [1] "7Networks_LH_Default_pCunPCC_21"
## 
## [[488]]
## [1] "7Networks_LH_Default_pCunPCC_22"
## 
## [[489]]
## [1] "7Networks_LH_Default_pCunPCC_23"
## 
## [[490]]
## [1] "7Networks_LH_Default_pCunPCC_24"
## 
## [[491]]
## [1] "7Networks_LH_Default_pCunPCC_25"
## 
## [[492]]
## [1] "7Networks_LH_Default_pCunPCC_26"
## 
## [[493]]
## [1] "7Networks_LH_Default_pCunPCC_27"
## 
## [[494]]
## [1] "7Networks_LH_Default_pCunPCC_28"
## 
## [[495]]
## [1] "7Networks_LH_Default_pCunPCC_29"
## 
## [[496]]
## [1] "7Networks_LH_Default_pCunPCC_30"
## 
## [[497]]
## [1] "7Networks_LH_Default_pCunPCC_31"
## 
## [[498]]
## [1] "7Networks_LH_Default_pCunPCC_32"
## 
## [[499]]
## [1] "7Networks_LH_Default_PHC_1"
## 
## [[500]]
## [1] "7Networks_LH_Default_PHC_2"
## 
## [[501]]
## [1] "7Networks_LH_Default_PHC_3"
## 
## [[502]]
## [1] "7Networks_RH_Vis_1"
## 
## [[503]]
## [1] "7Networks_RH_Vis_2"
## 
## [[504]]
## [1] "7Networks_RH_Vis_3"
## 
## [[505]]
## [1] "7Networks_RH_Vis_4"
## 
## [[506]]
## [1] "7Networks_RH_Vis_5"
## 
## [[507]]
## [1] "7Networks_RH_Vis_6"
## 
## [[508]]
## [1] "7Networks_RH_Vis_7"
## 
## [[509]]
## [1] "7Networks_RH_Vis_8"
## 
## [[510]]
## [1] "7Networks_RH_Vis_9"
## 
## [[511]]
## [1] "7Networks_RH_Vis_10"
## 
## [[512]]
## [1] "7Networks_RH_Vis_11"
## 
## [[513]]
## [1] "7Networks_RH_Vis_12"
## 
## [[514]]
## [1] "7Networks_RH_Vis_13"
## 
## [[515]]
## [1] "7Networks_RH_Vis_14"
## 
## [[516]]
## [1] "7Networks_RH_Vis_15"
## 
## [[517]]
## [1] "7Networks_RH_Vis_16"
## 
## [[518]]
## [1] "7Networks_RH_Vis_17"
## 
## [[519]]
## [1] "7Networks_RH_Vis_18"
## 
## [[520]]
## [1] "7Networks_RH_Vis_19"
## 
## [[521]]
## [1] "7Networks_RH_Vis_20"
## 
## [[522]]
## [1] "7Networks_RH_Vis_21"
## 
## [[523]]
## [1] "7Networks_RH_Vis_22"
## 
## [[524]]
## [1] "7Networks_RH_Vis_23"
## 
## [[525]]
## [1] "7Networks_RH_Vis_24"
## 
## [[526]]
## [1] "7Networks_RH_Vis_25"
## 
## [[527]]
## [1] "7Networks_RH_Vis_26"
## 
## [[528]]
## [1] "7Networks_RH_Vis_27"
## 
## [[529]]
## [1] "7Networks_RH_Vis_28"
## 
## [[530]]
## [1] "7Networks_RH_Vis_29"
## 
## [[531]]
## [1] "7Networks_RH_Vis_30"
## 
## [[532]]
## [1] "7Networks_RH_Vis_31"
## 
## [[533]]
## [1] "7Networks_RH_Vis_32"
## 
## [[534]]
## [1] "7Networks_RH_Vis_33"
## 
## [[535]]
## [1] "7Networks_RH_Vis_34"
## 
## [[536]]
## [1] "7Networks_RH_Vis_35"
## 
## [[537]]
## [1] "7Networks_RH_Vis_36"
## 
## [[538]]
## [1] "7Networks_RH_Vis_37"
## 
## [[539]]
## [1] "7Networks_RH_Vis_38"
## 
## [[540]]
## [1] "7Networks_RH_Vis_39"
## 
## [[541]]
## [1] "7Networks_RH_Vis_40"
## 
## [[542]]
## [1] "7Networks_RH_Vis_41"
## 
## [[543]]
## [1] "7Networks_RH_Vis_42"
## 
## [[544]]
## [1] "7Networks_RH_Vis_43"
## 
## [[545]]
## [1] "7Networks_RH_Vis_44"
## 
## [[546]]
## [1] "7Networks_RH_Vis_45"
## 
## [[547]]
## [1] "7Networks_RH_Vis_46"
## 
## [[548]]
## [1] "7Networks_RH_Vis_47"
## 
## [[549]]
## [1] "7Networks_RH_Vis_48"
## 
## [[550]]
## [1] "7Networks_RH_Vis_49"
## 
## [[551]]
## [1] "7Networks_RH_Vis_50"
## 
## [[552]]
## [1] "7Networks_RH_Vis_51"
## 
## [[553]]
## [1] "7Networks_RH_Vis_52"
## 
## [[554]]
## [1] "7Networks_RH_Vis_53"
## 
## [[555]]
## [1] "7Networks_RH_Vis_54"
## 
## [[556]]
## [1] "7Networks_RH_Vis_55"
## 
## [[557]]
## [1] "7Networks_RH_Vis_56"
## 
## [[558]]
## [1] "7Networks_RH_Vis_57"
## 
## [[559]]
## [1] "7Networks_RH_Vis_58"
## 
## [[560]]
## [1] "7Networks_RH_Vis_59"
## 
## [[561]]
## [1] "7Networks_RH_Vis_60"
## 
## [[562]]
## [1] "7Networks_RH_Vis_61"
## 
## [[563]]
## [1] "7Networks_RH_Vis_62"
## 
## [[564]]
## [1] "7Networks_RH_Vis_63"
## 
## [[565]]
## [1] "7Networks_RH_Vis_64"
## 
## [[566]]
## [1] "7Networks_RH_Vis_65"
## 
## [[567]]
## [1] "7Networks_RH_Vis_66"
## 
## [[568]]
## [1] "7Networks_RH_Vis_67"
## 
## [[569]]
## [1] "7Networks_RH_Vis_68"
## 
## [[570]]
## [1] "7Networks_RH_Vis_69"
## 
## [[571]]
## [1] "7Networks_RH_Vis_70"
## 
## [[572]]
## [1] "7Networks_RH_Vis_71"
## 
## [[573]]
## [1] "7Networks_RH_Vis_72"
## 
## [[574]]
## [1] "7Networks_RH_Vis_73"
## 
## [[575]]
## [1] "7Networks_RH_Vis_74"
## 
## [[576]]
## [1] "7Networks_RH_Vis_75"
## 
## [[577]]
## [1] "7Networks_RH_Vis_76"
## 
## [[578]]
## [1] "7Networks_RH_Vis_77"
## 
## [[579]]
## [1] "7Networks_RH_Vis_78"
## 
## [[580]]
## [1] "7Networks_RH_Vis_79"
## 
## [[581]]
## [1] "7Networks_RH_Vis_80"
## 
## [[582]]
## [1] "7Networks_RH_Vis_81"
## 
## [[583]]
## [1] "7Networks_RH_SomMot_1"
## 
## [[584]]
## [1] "7Networks_RH_SomMot_2"
## 
## [[585]]
## [1] "7Networks_RH_SomMot_3"
## 
## [[586]]
## [1] "7Networks_RH_SomMot_4"
## 
## [[587]]
## [1] "7Networks_RH_SomMot_5"
## 
## [[588]]
## [1] "7Networks_RH_SomMot_6"
## 
## [[589]]
## [1] "7Networks_RH_SomMot_7"
## 
## [[590]]
## [1] "7Networks_RH_SomMot_8"
## 
## [[591]]
## [1] "7Networks_RH_SomMot_9"
## 
## [[592]]
## [1] "7Networks_RH_SomMot_10"
## 
## [[593]]
## [1] "7Networks_RH_SomMot_11"
## 
## [[594]]
## [1] "7Networks_RH_SomMot_12"
## 
## [[595]]
## [1] "7Networks_RH_SomMot_13"
## 
## [[596]]
## [1] "7Networks_RH_SomMot_14"
## 
## [[597]]
## [1] "7Networks_RH_SomMot_15"
## 
## [[598]]
## [1] "7Networks_RH_SomMot_16"
## 
## [[599]]
## [1] "7Networks_RH_SomMot_17"
## 
## [[600]]
## [1] "7Networks_RH_SomMot_18"
## 
## [[601]]
## [1] "7Networks_RH_SomMot_19"
## 
## [[602]]
## [1] "7Networks_RH_SomMot_20"
## 
## [[603]]
## [1] "7Networks_RH_SomMot_21"
## 
## [[604]]
## [1] "7Networks_RH_SomMot_22"
## 
## [[605]]
## [1] "7Networks_RH_SomMot_23"
## 
## [[606]]
## [1] "7Networks_RH_SomMot_24"
## 
## [[607]]
## [1] "7Networks_RH_SomMot_25"
## 
## [[608]]
## [1] "7Networks_RH_SomMot_26"
## 
## [[609]]
## [1] "7Networks_RH_SomMot_27"
## 
## [[610]]
## [1] "7Networks_RH_SomMot_28"
## 
## [[611]]
## [1] "7Networks_RH_SomMot_29"
## 
## [[612]]
## [1] "7Networks_RH_SomMot_30"
## 
## [[613]]
## [1] "7Networks_RH_SomMot_31"
## 
## [[614]]
## [1] "7Networks_RH_SomMot_32"
## 
## [[615]]
## [1] "7Networks_RH_SomMot_33"
## 
## [[616]]
## [1] "7Networks_RH_SomMot_34"
## 
## [[617]]
## [1] "7Networks_RH_SomMot_35"
## 
## [[618]]
## [1] "7Networks_RH_SomMot_36"
## 
## [[619]]
## [1] "7Networks_RH_SomMot_37"
## 
## [[620]]
## [1] "7Networks_RH_SomMot_38"
## 
## [[621]]
## [1] "7Networks_RH_SomMot_39"
## 
## [[622]]
## [1] "7Networks_RH_SomMot_40"
## 
## [[623]]
## [1] "7Networks_RH_SomMot_41"
## 
## [[624]]
## [1] "7Networks_RH_SomMot_42"
## 
## [[625]]
## [1] "7Networks_RH_SomMot_43"
## 
## [[626]]
## [1] "7Networks_RH_SomMot_44"
## 
## [[627]]
## [1] "7Networks_RH_SomMot_45"
## 
## [[628]]
## [1] "7Networks_RH_SomMot_46"
## 
## [[629]]
## [1] "7Networks_RH_SomMot_47"
## 
## [[630]]
## [1] "7Networks_RH_SomMot_48"
## 
## [[631]]
## [1] "7Networks_RH_SomMot_49"
## 
## [[632]]
## [1] "7Networks_RH_SomMot_50"
## 
## [[633]]
## [1] "7Networks_RH_SomMot_51"
## 
## [[634]]
## [1] "7Networks_RH_SomMot_52"
## 
## [[635]]
## [1] "7Networks_RH_SomMot_53"
## 
## [[636]]
## [1] "7Networks_RH_SomMot_54"
## 
## [[637]]
## [1] "7Networks_RH_SomMot_55"
## 
## [[638]]
## [1] "7Networks_RH_SomMot_56"
## 
## [[639]]
## [1] "7Networks_RH_SomMot_57"
## 
## [[640]]
## [1] "7Networks_RH_SomMot_58"
## 
## [[641]]
## [1] "7Networks_RH_SomMot_59"
## 
## [[642]]
## [1] "7Networks_RH_SomMot_60"
## 
## [[643]]
## [1] "7Networks_RH_SomMot_61"
## 
## [[644]]
## [1] "7Networks_RH_SomMot_62"
## 
## [[645]]
## [1] "7Networks_RH_SomMot_63"
## 
## [[646]]
## [1] "7Networks_RH_SomMot_64"
## 
## [[647]]
## [1] "7Networks_RH_SomMot_65"
## 
## [[648]]
## [1] "7Networks_RH_SomMot_66"
## 
## [[649]]
## [1] "7Networks_RH_SomMot_67"
## 
## [[650]]
## [1] "7Networks_RH_SomMot_68"
## 
## [[651]]
## [1] "7Networks_RH_SomMot_69"
## 
## [[652]]
## [1] "7Networks_RH_SomMot_70"
## 
## [[653]]
## [1] "7Networks_RH_SomMot_71"
## 
## [[654]]
## [1] "7Networks_RH_SomMot_72"
## 
## [[655]]
## [1] "7Networks_RH_SomMot_73"
## 
## [[656]]
## [1] "7Networks_RH_SomMot_74"
## 
## [[657]]
## [1] "7Networks_RH_SomMot_75"
## 
## [[658]]
## [1] "7Networks_RH_SomMot_76"
## 
## [[659]]
## [1] "7Networks_RH_SomMot_77"
## 
## [[660]]
## [1] "7Networks_RH_SomMot_78"
## 
## [[661]]
## [1] "7Networks_RH_SomMot_79"
## 
## [[662]]
## [1] "7Networks_RH_SomMot_80"
## 
## [[663]]
## [1] "7Networks_RH_SomMot_81"
## 
## [[664]]
## [1] "7Networks_RH_SomMot_82"
## 
## [[665]]
## [1] "7Networks_RH_SomMot_83"
## 
## [[666]]
## [1] "7Networks_RH_SomMot_84"
## 
## [[667]]
## [1] "7Networks_RH_SomMot_85"
## 
## [[668]]
## [1] "7Networks_RH_SomMot_86"
## 
## [[669]]
## [1] "7Networks_RH_SomMot_87"
## 
## [[670]]
## [1] "7Networks_RH_SomMot_88"
## 
## [[671]]
## [1] "7Networks_RH_SomMot_89"
## 
## [[672]]
## [1] "7Networks_RH_SomMot_90"
## 
## [[673]]
## [1] "7Networks_RH_SomMot_91"
## 
## [[674]]
## [1] "7Networks_RH_SomMot_92"
## 
## [[675]]
## [1] "7Networks_RH_SomMot_93"
## 
## [[676]]
## [1] "7Networks_RH_SomMot_94"
## 
## [[677]]
## [1] "7Networks_RH_SomMot_95"
## 
## [[678]]
## [1] "7Networks_RH_SomMot_96"
## 
## [[679]]
## [1] "7Networks_RH_SomMot_97"
## 
## [[680]]
## [1] "7Networks_RH_SomMot_98"
## 
## [[681]]
## [1] "7Networks_RH_SomMot_99"
## 
## [[682]]
## [1] "7Networks_RH_SomMot_100"
## 
## [[683]]
## [1] "7Networks_RH_SomMot_101"
## 
## [[684]]
## [1] "7Networks_RH_SomMot_102"
## 
## [[685]]
## [1] "7Networks_RH_SomMot_103"
## 
## [[686]]
## [1] "7Networks_RH_DorsAttn_Post_1"
## 
## [[687]]
## [1] "7Networks_RH_DorsAttn_Post_2"
## 
## [[688]]
## [1] "7Networks_RH_DorsAttn_Post_3"
## 
## [[689]]
## [1] "7Networks_RH_DorsAttn_Post_4"
## 
## [[690]]
## [1] "7Networks_RH_DorsAttn_Post_5"
## 
## [[691]]
## [1] "7Networks_RH_DorsAttn_Post_6"
## 
## [[692]]
## [1] "7Networks_RH_DorsAttn_Post_7"
## 
## [[693]]
## [1] "7Networks_RH_DorsAttn_Post_8"
## 
## [[694]]
## [1] "7Networks_RH_DorsAttn_Post_9"
## 
## [[695]]
## [1] "7Networks_RH_DorsAttn_Post_10"
## 
## [[696]]
## [1] "7Networks_RH_DorsAttn_Post_11"
## 
## [[697]]
## [1] "7Networks_RH_DorsAttn_Post_12"
## 
## [[698]]
## [1] "7Networks_RH_DorsAttn_Post_13"
## 
## [[699]]
## [1] "7Networks_RH_DorsAttn_Post_14"
## 
## [[700]]
## [1] "7Networks_RH_DorsAttn_Post_15"
## 
## [[701]]
## [1] "7Networks_RH_DorsAttn_Post_16"
## 
## [[702]]
## [1] "7Networks_RH_DorsAttn_Post_17"
## 
## [[703]]
## [1] "7Networks_RH_DorsAttn_Post_18"
## 
## [[704]]
## [1] "7Networks_RH_DorsAttn_Post_19"
## 
## [[705]]
## [1] "7Networks_RH_DorsAttn_Post_20"
## 
## [[706]]
## [1] "7Networks_RH_DorsAttn_Post_21"
## 
## [[707]]
## [1] "7Networks_RH_DorsAttn_Post_22"
## 
## [[708]]
## [1] "7Networks_RH_DorsAttn_Post_23"
## 
## [[709]]
## [1] "7Networks_RH_DorsAttn_Post_24"
## 
## [[710]]
## [1] "7Networks_RH_DorsAttn_Post_25"
## 
## [[711]]
## [1] "7Networks_RH_DorsAttn_Post_26"
## 
## [[712]]
## [1] "7Networks_RH_DorsAttn_Post_27"
## 
## [[713]]
## [1] "7Networks_RH_DorsAttn_Post_28"
## 
## [[714]]
## [1] "7Networks_RH_DorsAttn_Post_29"
## 
## [[715]]
## [1] "7Networks_RH_DorsAttn_Post_30"
## 
## [[716]]
## [1] "7Networks_RH_DorsAttn_Post_31"
## 
## [[717]]
## [1] "7Networks_RH_DorsAttn_Post_32"
## 
## [[718]]
## [1] "7Networks_RH_DorsAttn_Post_33"
## 
## [[719]]
## [1] "7Networks_RH_DorsAttn_Post_34"
## 
## [[720]]
## [1] "7Networks_RH_DorsAttn_Post_35"
## 
## [[721]]
## [1] "7Networks_RH_DorsAttn_Post_36"
## 
## [[722]]
## [1] "7Networks_RH_DorsAttn_Post_37"
## 
## [[723]]
## [1] "7Networks_RH_DorsAttn_Post_38"
## 
## [[724]]
## [1] "7Networks_RH_DorsAttn_Post_39"
## 
## [[725]]
## [1] "7Networks_RH_DorsAttn_Post_40"
## 
## [[726]]
## [1] "7Networks_RH_DorsAttn_Post_41"
## 
## [[727]]
## [1] "7Networks_RH_DorsAttn_Post_42"
## 
## [[728]]
## [1] "7Networks_RH_DorsAttn_Post_43"
## 
## [[729]]
## [1] "7Networks_RH_DorsAttn_Post_44"
## 
## [[730]]
## [1] "7Networks_RH_DorsAttn_Post_45"
## 
## [[731]]
## [1] "7Networks_RH_DorsAttn_Post_46"
## 
## [[732]]
## [1] "7Networks_RH_DorsAttn_Post_47"
## 
## [[733]]
## [1] "7Networks_RH_DorsAttn_Post_48"
## 
## [[734]]
## [1] "7Networks_RH_DorsAttn_Post_49"
## 
## [[735]]
## [1] "7Networks_RH_DorsAttn_Post_50"
## 
## [[736]]
## [1] "7Networks_RH_DorsAttn_Post_51"
## 
## [[737]]
## [1] "7Networks_RH_DorsAttn_Post_52"
## 
## [[738]]
## [1] "7Networks_RH_DorsAttn_FEF_1"
## 
## [[739]]
## [1] "7Networks_RH_DorsAttn_FEF_2"
## 
## [[740]]
## [1] "7Networks_RH_DorsAttn_FEF_3"
## 
## [[741]]
## [1] "7Networks_RH_DorsAttn_FEF_4"
## 
## [[742]]
## [1] "7Networks_RH_DorsAttn_FEF_5"
## 
## [[743]]
## [1] "7Networks_RH_DorsAttn_FEF_6"
## 
## [[744]]
## [1] "7Networks_RH_DorsAttn_PrCv_1"
## 
## [[745]]
## [1] "7Networks_RH_DorsAttn_PrCv_2"
## 
## [[746]]
## [1] "7Networks_RH_DorsAttn_PrCv_3"
## 
## [[747]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_1"
## 
## [[748]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_2"
## 
## [[749]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_3"
## 
## [[750]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_4"
## 
## [[751]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_5"
## 
## [[752]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_6"
## 
## [[753]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_7"
## 
## [[754]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_8"
## 
## [[755]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_9"
## 
## [[756]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_10"
## 
## [[757]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_11"
## 
## [[758]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_12"
## 
## [[759]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_13"
## 
## [[760]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_14"
## 
## [[761]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_15"
## 
## [[762]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_16"
## 
## [[763]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_17"
## 
## [[764]]
## [1] "7Networks_RH_SalVentAttn_TempOccPar_18"
## 
## [[765]]
## [1] "7Networks_RH_SalVentAttn_PrC_1"
## 
## [[766]]
## [1] "7Networks_RH_SalVentAttn_PrC_2"
## 
## [[767]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_1"
## 
## [[768]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_2"
## 
## [[769]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_3"
## 
## [[770]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_4"
## 
## [[771]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_5"
## 
## [[772]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_6"
## 
## [[773]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_7"
## 
## [[774]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_8"
## 
## [[775]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_9"
## 
## [[776]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_10"
## 
## [[777]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_11"
## 
## [[778]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_12"
## 
## [[779]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_13"
## 
## [[780]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_14"
## 
## [[781]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_15"
## 
## [[782]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_16"
## 
## [[783]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_17"
## 
## [[784]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_18"
## 
## [[785]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_19"
## 
## [[786]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_20"
## 
## [[787]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_21"
## 
## [[788]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_22"
## 
## [[789]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_23"
## 
## [[790]]
## [1] "7Networks_RH_SalVentAttn_FrOperIns_24"
## 
## [[791]]
## [1] "7Networks_RH_SalVentAttn_PFCl_1"
## 
## [[792]]
## [1] "7Networks_RH_SalVentAttn_PFCl_2"
## 
## [[793]]
## [1] "7Networks_RH_SalVentAttn_Med_1"
## 
## [[794]]
## [1] "7Networks_RH_SalVentAttn_Med_2"
## 
## [[795]]
## [1] "7Networks_RH_SalVentAttn_Med_3"
## 
## [[796]]
## [1] "7Networks_RH_SalVentAttn_Med_4"
## 
## [[797]]
## [1] "7Networks_RH_SalVentAttn_Med_5"
## 
## [[798]]
## [1] "7Networks_RH_SalVentAttn_Med_6"
## 
## [[799]]
## [1] "7Networks_RH_SalVentAttn_Med_7"
## 
## [[800]]
## [1] "7Networks_RH_SalVentAttn_Med_8"
## 
## [[801]]
## [1] "7Networks_RH_SalVentAttn_Med_9"
## 
## [[802]]
## [1] "7Networks_RH_SalVentAttn_Med_10"
## 
## [[803]]
## [1] "7Networks_RH_SalVentAttn_Med_11"
## 
## [[804]]
## [1] "7Networks_RH_SalVentAttn_Med_12"
## 
## [[805]]
## [1] "7Networks_RH_SalVentAttn_Med_13"
## 
## [[806]]
## [1] "7Networks_RH_SalVentAttn_Med_14"
## 
## [[807]]
## [1] "7Networks_RH_SalVentAttn_Med_15"
## 
## [[808]]
## [1] "7Networks_RH_SalVentAttn_Med_16"
## 
## [[809]]
## [1] "7Networks_RH_SalVentAttn_Med_17"
## 
## [[810]]
## [1] "7Networks_RH_SalVentAttn_Med_18"
## 
## [[811]]
## [1] "7Networks_RH_SalVentAttn_Med_19"
## 
## [[812]]
## [1] "7Networks_RH_SalVentAttn_Med_20"
## 
## [[813]]
## [1] "7Networks_RH_Limbic_OFC_1"
## 
## [[814]]
## [1] "7Networks_RH_Limbic_OFC_2"
## 
## [[815]]
## [1] "7Networks_RH_Limbic_OFC_3"
## 
## [[816]]
## [1] "7Networks_RH_Limbic_OFC_4"
## 
## [[817]]
## [1] "7Networks_RH_Limbic_OFC_5"
## 
## [[818]]
## [1] "7Networks_RH_Limbic_OFC_6"
## 
## [[819]]
## [1] "7Networks_RH_Limbic_OFC_7"
## 
## [[820]]
## [1] "7Networks_RH_Limbic_OFC_8"
## 
## [[821]]
## [1] "7Networks_RH_Limbic_OFC_9"
## 
## [[822]]
## [1] "7Networks_RH_Limbic_OFC_10"
## 
## [[823]]
## [1] "7Networks_RH_Limbic_OFC_11"
## 
## [[824]]
## [1] "7Networks_RH_Limbic_OFC_12"
## 
## [[825]]
## [1] "7Networks_RH_Limbic_OFC_13"
## 
## [[826]]
## [1] "7Networks_RH_Limbic_OFC_14"
## 
## [[827]]
## [1] "7Networks_RH_Limbic_TempPole_1"
## 
## [[828]]
## [1] "7Networks_RH_Limbic_TempPole_2"
## 
## [[829]]
## [1] "7Networks_RH_Limbic_TempPole_3"
## 
## [[830]]
## [1] "7Networks_RH_Limbic_TempPole_4"
## 
## [[831]]
## [1] "7Networks_RH_Limbic_TempPole_5"
## 
## [[832]]
## [1] "7Networks_RH_Limbic_TempPole_6"
## 
## [[833]]
## [1] "7Networks_RH_Limbic_TempPole_7"
## 
## [[834]]
## [1] "7Networks_RH_Limbic_TempPole_8"
## 
## [[835]]
## [1] "7Networks_RH_Limbic_TempPole_9"
## 
## [[836]]
## [1] "7Networks_RH_Limbic_TempPole_10"
## 
## [[837]]
## [1] "7Networks_RH_Limbic_TempPole_11"
## 
## [[838]]
## [1] "7Networks_RH_Limbic_TempPole_12"
## 
## [[839]]
## [1] "7Networks_RH_Limbic_TempPole_13"
## 
## [[840]]
## [1] "7Networks_RH_Limbic_TempPole_14"
## 
## [[841]]
## [1] "7Networks_RH_Limbic_TempPole_15"
## 
## [[842]]
## [1] "7Networks_RH_Limbic_TempPole_16"
## 
## [[843]]
## [1] "7Networks_RH_Limbic_TempPole_17"
## 
## [[844]]
## [1] "7Networks_RH_Cont_Par_1"
## 
## [[845]]
## [1] "7Networks_RH_Cont_Par_2"
## 
## [[846]]
## [1] "7Networks_RH_Cont_Par_3"
## 
## [[847]]
## [1] "7Networks_RH_Cont_Par_4"
## 
## [[848]]
## [1] "7Networks_RH_Cont_Par_5"
## 
## [[849]]
## [1] "7Networks_RH_Cont_Par_6"
## 
## [[850]]
## [1] "7Networks_RH_Cont_Par_7"
## 
## [[851]]
## [1] "7Networks_RH_Cont_Par_8"
## 
## [[852]]
## [1] "7Networks_RH_Cont_Par_9"
## 
## [[853]]
## [1] "7Networks_RH_Cont_Par_10"
## 
## [[854]]
## [1] "7Networks_RH_Cont_Par_11"
## 
## [[855]]
## [1] "7Networks_RH_Cont_Par_12"
## 
## [[856]]
## [1] "7Networks_RH_Cont_Par_13"
## 
## [[857]]
## [1] "7Networks_RH_Cont_Par_14"
## 
## [[858]]
## [1] "7Networks_RH_Cont_Par_15"
## 
## [[859]]
## [1] "7Networks_RH_Cont_Par_16"
## 
## [[860]]
## [1] "7Networks_RH_Cont_Par_17"
## 
## [[861]]
## [1] "7Networks_RH_Cont_Temp_1"
## 
## [[862]]
## [1] "7Networks_RH_Cont_Temp_2"
## 
## [[863]]
## [1] "7Networks_RH_Cont_Temp_3"
## 
## [[864]]
## [1] "7Networks_RH_Cont_Temp_4"
## 
## [[865]]
## [1] "7Networks_RH_Cont_PFCv_1"
## 
## [[866]]
## [1] "7Networks_RH_Cont_PFCv_2"
## 
## [[867]]
## [1] "7Networks_RH_Cont_PFCl_1"
## 
## [[868]]
## [1] "7Networks_RH_Cont_PFCl_2"
## 
## [[869]]
## [1] "7Networks_RH_Cont_PFCl_3"
## 
## [[870]]
## [1] "7Networks_RH_Cont_PFCl_4"
## 
## [[871]]
## [1] "7Networks_RH_Cont_PFCl_5"
## 
## [[872]]
## [1] "7Networks_RH_Cont_PFCl_6"
## 
## [[873]]
## [1] "7Networks_RH_Cont_PFCl_7"
## 
## [[874]]
## [1] "7Networks_RH_Cont_PFCl_8"
## 
## [[875]]
## [1] "7Networks_RH_Cont_PFCl_9"
## 
## [[876]]
## [1] "7Networks_RH_Cont_PFCl_10"
## 
## [[877]]
## [1] "7Networks_RH_Cont_PFCl_11"
## 
## [[878]]
## [1] "7Networks_RH_Cont_PFCl_12"
## 
## [[879]]
## [1] "7Networks_RH_Cont_PFCl_13"
## 
## [[880]]
## [1] "7Networks_RH_Cont_PFCl_14"
## 
## [[881]]
## [1] "7Networks_RH_Cont_PFCl_15"
## 
## [[882]]
## [1] "7Networks_RH_Cont_PFCl_16"
## 
## [[883]]
## [1] "7Networks_RH_Cont_PFCl_17"
## 
## [[884]]
## [1] "7Networks_RH_Cont_PFCl_18"
## 
## [[885]]
## [1] "7Networks_RH_Cont_PFCl_19"
## 
## [[886]]
## [1] "7Networks_RH_Cont_PFCl_20"
## 
## [[887]]
## [1] "7Networks_RH_Cont_PFCl_21"
## 
## [[888]]
## [1] "7Networks_RH_Cont_PFCl_22"
## 
## [[889]]
## [1] "7Networks_RH_Cont_PFCl_23"
## 
## [[890]]
## [1] "7Networks_RH_Cont_PFCl_24"
## 
## [[891]]
## [1] "7Networks_RH_Cont_PFCl_25"
## 
## [[892]]
## [1] "7Networks_RH_Cont_PFCl_26"
## 
## [[893]]
## [1] "7Networks_RH_Cont_PFCl_27"
## 
## [[894]]
## [1] "7Networks_RH_Cont_PFCl_28"
## 
## [[895]]
## [1] "7Networks_RH_Cont_PFCl_29"
## 
## [[896]]
## [1] "7Networks_RH_Cont_PFCl_30"
## 
## [[897]]
## [1] "7Networks_RH_Cont_PFCl_31"
## 
## [[898]]
## [1] "7Networks_RH_Cont_PFCl_32"
## 
## [[899]]
## [1] "7Networks_RH_Cont_PFCl_33"
## 
## [[900]]
## [1] "7Networks_RH_Cont_PFCl_34"
## 
## [[901]]
## [1] "7Networks_RH_Cont_pCun_1"
## 
## [[902]]
## [1] "7Networks_RH_Cont_pCun_3"
## 
## [[903]]
## [1] "7Networks_RH_Cont_pCun_5"
## 
## [[904]]
## [1] "7Networks_RH_Cont_Cing_1"
## 
## [[905]]
## [1] "7Networks_RH_Cont_Cing_2"
## 
## [[906]]
## [1] "7Networks_RH_Cont_Cing_3"
## 
## [[907]]
## [1] "7Networks_RH_Cont_Cing_4"
## 
## [[908]]
## [1] "7Networks_RH_Cont_Cing_5"
## 
## [[909]]
## [1] "7Networks_RH_Cont_PFCmp_1"
## 
## [[910]]
## [1] "7Networks_RH_Cont_PFCmp_2"
## 
## [[911]]
## [1] "7Networks_RH_Cont_PFCmp_3"
## 
## [[912]]
## [1] "7Networks_RH_Cont_PFCmp_4"
## 
## [[913]]
## [1] "7Networks_RH_Cont_PFCmp_5"
## 
## [[914]]
## [1] "7Networks_RH_Default_Par_1"
## 
## [[915]]
## [1] "7Networks_RH_Default_Par_2"
## 
## [[916]]
## [1] "7Networks_RH_Default_Par_3"
## 
## [[917]]
## [1] "7Networks_RH_Default_Par_4"
## 
## [[918]]
## [1] "7Networks_RH_Default_Par_5"
## 
## [[919]]
## [1] "7Networks_RH_Default_Par_6"
## 
## [[920]]
## [1] "7Networks_RH_Default_Par_7"
## 
## [[921]]
## [1] "7Networks_RH_Default_Par_8"
## 
## [[922]]
## [1] "7Networks_RH_Default_Par_9"
## 
## [[923]]
## [1] "7Networks_RH_Default_Par_10"
## 
## [[924]]
## [1] "7Networks_RH_Default_Par_11"
## 
## [[925]]
## [1] "7Networks_RH_Default_Par_12"
## 
## [[926]]
## [1] "7Networks_RH_Default_Par_13"
## 
## [[927]]
## [1] "7Networks_RH_Default_Par_14"
## 
## [[928]]
## [1] "7Networks_RH_Default_Par_15"
## 
## [[929]]
## [1] "7Networks_RH_Default_Par_16"
## 
## [[930]]
## [1] "7Networks_RH_Default_Temp_1"
## 
## [[931]]
## [1] "7Networks_RH_Default_Temp_2"
## 
## [[932]]
## [1] "7Networks_RH_Default_Temp_3"
## 
## [[933]]
## [1] "7Networks_RH_Default_Temp_4"
## 
## [[934]]
## [1] "7Networks_RH_Default_Temp_5"
## 
## [[935]]
## [1] "7Networks_RH_Default_Temp_6"
## 
## [[936]]
## [1] "7Networks_RH_Default_Temp_7"
## 
## [[937]]
## [1] "7Networks_RH_Default_Temp_8"
## 
## [[938]]
## [1] "7Networks_RH_Default_Temp_9"
## 
## [[939]]
## [1] "7Networks_RH_Default_Temp_10"
## 
## [[940]]
## [1] "7Networks_RH_Default_Temp_11"
## 
## [[941]]
## [1] "7Networks_RH_Default_Temp_12"
## 
## [[942]]
## [1] "7Networks_RH_Default_Temp_13"
## 
## [[943]]
## [1] "7Networks_RH_Default_Temp_14"
## 
## [[944]]
## [1] "7Networks_RH_Default_Temp_15"
## 
## [[945]]
## [1] "7Networks_RH_Default_Temp_16"
## 
## [[946]]
## [1] "7Networks_RH_Default_Temp_17"
## 
## [[947]]
## [1] "7Networks_RH_Default_Temp_18"
## 
## [[948]]
## [1] "7Networks_RH_Default_PFCv_1"
## 
## [[949]]
## [1] "7Networks_RH_Default_PFCv_2"
## 
## [[950]]
## [1] "7Networks_RH_Default_PFCv_3"
## 
## [[951]]
## [1] "7Networks_RH_Default_PFCv_4"
## 
## [[952]]
## [1] "7Networks_RH_Default_PFCv_5"
## 
## [[953]]
## [1] "7Networks_RH_Default_PFCv_6"
## 
## [[954]]
## [1] "7Networks_RH_Default_PFCv_7"
## 
## [[955]]
## [1] "7Networks_RH_Default_PFCv_8"
## 
## [[956]]
## [1] "7Networks_RH_Default_PFCv_9"
## 
## [[957]]
## [1] "7Networks_RH_Default_PFCv_10"
## 
## [[958]]
## [1] "7Networks_RH_Default_PFCdPFCm_1"
## 
## [[959]]
## [1] "7Networks_RH_Default_PFCdPFCm_2"
## 
## [[960]]
## [1] "7Networks_RH_Default_PFCdPFCm_3"
## 
## [[961]]
## [1] "7Networks_RH_Default_PFCdPFCm_4"
## 
## [[962]]
## [1] "7Networks_RH_Default_PFCdPFCm_5"
## 
## [[963]]
## [1] "7Networks_RH_Default_PFCdPFCm_6"
## 
## [[964]]
## [1] "7Networks_RH_Default_PFCdPFCm_7"
## 
## [[965]]
## [1] "7Networks_RH_Default_PFCdPFCm_8"
## 
## [[966]]
## [1] "7Networks_RH_Default_PFCdPFCm_9"
## 
## [[967]]
## [1] "7Networks_RH_Default_PFCdPFCm_10"
## 
## [[968]]
## [1] "7Networks_RH_Default_PFCdPFCm_11"
## 
## [[969]]
## [1] "7Networks_RH_Default_PFCdPFCm_12"
## 
## [[970]]
## [1] "7Networks_RH_Default_PFCdPFCm_13"
## 
## [[971]]
## [1] "7Networks_RH_Default_PFCdPFCm_14"
## 
## [[972]]
## [1] "7Networks_RH_Default_PFCdPFCm_15"
## 
## [[973]]
## [1] "7Networks_RH_Default_PFCdPFCm_16"
## 
## [[974]]
## [1] "7Networks_RH_Default_PFCdPFCm_17"
## 
## [[975]]
## [1] "7Networks_RH_Default_PFCdPFCm_18"
## 
## [[976]]
## [1] "7Networks_RH_Default_PFCdPFCm_19"
## 
## [[977]]
## [1] "7Networks_RH_Default_PFCdPFCm_20"
## 
## [[978]]
## [1] "7Networks_RH_Default_PFCdPFCm_21"
## 
## [[979]]
## [1] "7Networks_RH_Default_PFCdPFCm_22"
## 
## [[980]]
## [1] "7Networks_RH_Default_PFCdPFCm_23"
## 
## [[981]]
## [1] "7Networks_RH_Default_PFCdPFCm_24"
## 
## [[982]]
## [1] "7Networks_RH_Default_pCunPCC_1"
## 
## [[983]]
## [1] "7Networks_RH_Default_pCunPCC_2"
## 
## [[984]]
## [1] "7Networks_RH_Default_pCunPCC_3"
## 
## [[985]]
## [1] "7Networks_RH_Default_pCunPCC_4"
## 
## [[986]]
## [1] "7Networks_RH_Default_pCunPCC_5"
## 
## [[987]]
## [1] "7Networks_RH_Default_pCunPCC_6"
## 
## [[988]]
## [1] "7Networks_RH_Default_pCunPCC_7"
## 
## [[989]]
## [1] "7Networks_RH_Default_pCunPCC_8"
## 
## [[990]]
## [1] "7Networks_RH_Default_pCunPCC_9"
## 
## [[991]]
## [1] "7Networks_RH_Default_pCunPCC_10"
## 
## [[992]]
## [1] "7Networks_RH_Default_pCunPCC_11"
## 
## [[993]]
## [1] "7Networks_RH_Default_pCunPCC_12"
## 
## [[994]]
## [1] "7Networks_RH_Default_pCunPCC_13"
## 
## [[995]]
## [1] "7Networks_RH_Default_pCunPCC_14"
## 
## [[996]]
## [1] "7Networks_RH_Default_pCunPCC_15"
## 
## [[997]]
## [1] "7Networks_RH_Default_pCunPCC_16"
## 
## [[998]]
## [1] "7Networks_RH_Default_pCunPCC_17"
## 
## [[999]]
## [1] "7Networks_RH_Default_pCunPCC_18"
## 
## [[1000]]
## [1] "7Networks_RH_Cont_pCun_2"
## 
## [[1001]]
## [1] "7Networks_RH_Cont_pCun_4"

dim(parcel_1000)

## [1]     1 64984

We need to map from Schaefer2018 1000 parcels to yeo2011 7 networks. *

map_network <- function(name) {
  # Split the name by '_'
  netname <- unlist(strsplit(name, "_"))[3]
  
  # Define the mapping
  if (netname == 'Vis') {
    return(1)
  } else if (netname == 'SomMot') {
    return(2)
  } else if (netname == 'DorsAttn') {
    return(3)
  } else if (netname == 'SalVentAttn') {
    return(4)
  } else if (netname == 'Limbic') {
    return(5)
  } else if (netname == 'Cont') {
    return(6)
  } else if (netname == 'Default') {
    return(7)
  } else {
    return(-1)  # Return -1 for unexpected values
  }
}
mapped_parcel_map <- unlist((sapply(parcel_labels[-1], map_network)))

networks <- unlist(lapply(parcel_1000, function(vertex) {
  return(mapped_parcel_map[vertex])
}))

# Create a binary vector indicating locations inside (1) or outside (0) the network 7.
net <- list(
  Default = as.integer(networks == 7) 
)


print(parcel_1000[1:10])

##  [1] 479 170 124 461  70 323 340   0  13 335

print(networks[1:10])

##  [1] 7 2 2 7 1 6 6 1 6 2

print(net$Default[1:10])

##  [1] 1 0 0 1 0 0 0 0 0 0

zero_indices <- which(parcel_1000 == 0)
X <- X[,-zero_indices]
dim(X)

## [1]   440 58606

length(net$Default)

## [1] 58606

After loading the data, we recommend checking that the dimensions of your input data are correct:

• dimension of X should be N x P (number of participants x number of image locations)

• dimension of phenotype vector y should be N

• dimensions of covariate/confounder vector or matrix Z should be N (x however many covariates you’re adjusting for)

Define the arguments.

The following dictionary of arguments are defined to passed to the nest method. The args can be defined as follows, assuming vertex-wise linear models will be fit to estimate local brain-phenotype associations (i.e., specifying statFun=“lm” in step 4.).

• X: N x P matrix of P imaging features (e.g., vertices) for N participants
• y: N-dimensional vector of the phenotype of interest (i.e., testing enrichment of X-y associations).
• Z: Optional. Specify one or more covariates (matrix with N rows and q columns for q covariates). Default is NULL (no covariates to be included).
• FL: Optional. Default is FALSE, set to TRUE to use the Freedman-Lane procedure to account for dependence between covariates in permutation.
• n.perm: Optional. Default is 999, with the smallest possible p-value of 1/1000.

args.lm <- list(
    X = X, # brain measurements (dimension N subjects x P image locations)
    y = age, # phenotype of interest (dimension N)
    Z = sex, # covariates (dimension (N x # number of covariates)
    type = "coef", # what type of test statistic to extract from linear regression model (note: if using a different type of model for statistic, this may be different. see source code)
    n.perm = 10 # how many permutations to use to obtain null distribution
)

Note: non-linear regression-based statistics can also be used. This example is just for the regression-based statistic.

Apply the NEST method

Arguments for NEST function: - statFun: specify the method to get vertex-level test statistics (e.g., “lm”). Must correspond to a statFun R script (e.g., statFun.lm.R or statFun.gam.mvwald.R, or another one customized by the user)

• args: arguments needed for whatever was specified as statFun

• net.maps: list of binary vector(s) indicating locations inside (1) or outside (0) network(s) of interest.

• one.sided: Specifies whether test is one-sided (one.sided=TRUE) or two-sided (one.sided = FALSE)

  • In a one-sided test, we test whether T(v) are more extreme in vs. outside the network
  • In a two-sided test, we test whether the distribution of T(v) is different in vs. outside the network.
  • Note: default is one.sided = TRUE, which is consistent with implementation used in the paper.

• n.cores: specify the number of CPU cores to be employed for parallel processing tasks within the function. Default is n.cores = 1 but increase for speedier computation time.

• seed: random seed for reproducible permutation. Default is NULL, but we recommend setting one.

• what.to.return: specify what values to return. "everything" will include p-value, enrichment score, null distribution, etc. If left unspecified, the default is to return only the p-value for each network.

out <- NEST(statFun = "lm",
            args = args.lm, # arguments defined above (specific to statFun="lm" setting)
            net.maps = net, 
            one.sided = TRUE,
            n.cores = 1, 
            seed = 10, 
            what.to.return = "everything")

out$ES
out$pval

Implementations in Python

Prepare the data

import necessary libraries for loading the data: - nibabel for reading and writing neuroimaging data. - numpy for numerical operations and array handling.

import nibabel as nb
import numpy as np

The following codes loads and preprocesses the brain imaging data and phenotype (e.g., demographic) information:

• Brain imaging data (cifti_data) is loaded from a .nii file.
• Network labels (network_label) are loaded and filtered to remove unspecified indices (-1).
• Binary vectors (net_7) are created for two specific networks, indicating vertex membership.
• Phenotype data (age, sex) is loaded and combined into a single array (phenotype).

# load brain imaging data
cifti_data = nb.load('./Dataset/HCP_WB_Tutorial_1.0/Q1-Q6_R440.All.sulc.32k_fs_LR.dscalar.nii').get_fdata(dtype=np.float32) # (replace with code to load your data)
network_labels = np.load('./Dataset/network_label_yeo7.npz')['arr_0'] # (replace with code to load your network labels)

idx = network_labels!=-1  # identify which locations should be ignored (e.g., medial wall)
network_label = network_labels[idx]  # remove labels outside idx
X = cifti_data[:,idx] # subset image (X) locations to idx

# generate binary vector for each network, 0-> specific vertex does not belong to the network, 1-> specific vertex belongs to the network.
net_7 = np.where(network_label!=7,0,1)  # create a binary vector with 1's at locations corresponding to network 7 and 0's at locations outside network 7

# Phenotype of interest (y) and covariates (Z)
y = np.load('./Dataset/R440_age.npz')['arr_0'] # replace with code to load your phenotype (e.g., age)
Z = np.load('./Dataset/R440_gender.npz')['arr_0'] # replace with code to load other covariates/confounders (e.g., sex)

Import the NEST package

The package can be installed via ‘pip install nest-sw’

from NEST import nest

Specify the auguments

Define the following dictionary of arguments passed to the nest method. The args can be defined as follows, assuming vertex-wise linear models will be fit to estimate local brain-phenotype associations (i.e., specifying statFun=‘lm’ in step 4.).

• X: N x P matrix (numpy array) of P imaging features (e.g., vertices) for N participants.

• y: N-dimensional vector of phenotype of interest (i.e., testing enrichment of X-y associations).

• Z: Optional. Specify one or more covariates (matrix with N rows and q columns for q covariates). Default is NULL (no covariates to be included).

• FL: Optional (default is False). Set to True to use Freedman-Lane procedure to account for dependence between covariates in permutation.

• n_perm: Optional (default is 999, with smallest possible p-value of 1/1000).

args = {
    'X': X, # brain measurements (dimension N subjects x P image locations).
    'y': y, # phenotype of interest (dimension N).
    'Z': Z, # covariates (dimension (N x # number of covariates).
    'type': 'coef', # what type of test statistic to extract from linear regression model.
    'FL': False, # Not use Freedman-Lane procedure.
    'n_perm': 999 # how many permutations to use to obtain null distribution.
}

Apply the NEST method

NEST method can be called through the function nest() with specified auguments.

pval,ES_obs,ES_null,_ = nest(statFun='lm', # use linear regression to get vertex-level test statistics
                             args=args, # arguments specified above (specific to statFun="lm")
                             net_maps=net_7, # list of binary indicating locations inside (1) or outside (1) network(s) of interest. just for one network, but could be for multiple
                             one_sided=True, # Determines whether the enrichment score calculation should consider only the positive alignment (True) or both directions (False).
                             seed=None, # Random seed for reproducible permutation. Default is None. 
                             )

NEST also supports the use of customized statistical functions for calculating associations. This advanced feature allows for more tailored analysis that fits specific research questions or datasets. To utilize a custom statistical function, specify the argument statFun = 'your_custom_function' alongside the corresponding arguments required by your function.

Additional resources

Tutorial for using NEST in Python is available at here.

More information: here

Feel free to reach out with any comments/questions!